Webilar mean fluorescence intensity of CD1a as epidermal CD1a+ILC2, although CD1a was present on a greater proportion of the LCs than ILC2 (Fig. 1, D to F). CD1a was not observed on epidermal T cells (Fig. 1G and fig. S1D). These findings suggested that subsets of skin-derived ILC2 express CD1a and therefore may be capable of presenting an- WebApr 16, 2024 · Langerhans cell histiocytosis (LCH) is a disease characterized by clonal expansion of myeloid precursors that differentiate into CD1a + /CD207 + in lesions. It presents at all ages with various degrees of systemic involvement, and although cure rates are high, severe long-term neurological or endocrine complications may affect quality of life.
CD1a presentation of endogenous antigens by group 2 innate
WebImmunohistochemically, the expression of S-100 protein, CD1a and langerin was 99.1% (209/211), 100% (206/206) and 98.5% (193/196), respectively, and the sensitivity of them had no statistical difference. Conclusions: No significant difference of the sensitivity is found among langerin, CD1a and S-100 expression in diagnosis of LCH. WebCD1a Antibodies. CD1a is a member of the lipid antigen presenting molecules family. Like the other CD1 proteins (group 1: CD1a, CD1b, CD1c and group 2: CD1d, CD1e), CD1a is … brazilian pfp
[Langerhans cell histiocytosis: a clinicopathologic and ... - PubMed
WebCD1a antibody is expressed in cells comprising Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma. CD1a antibody has been used to differentiate various cutaneous Lymphomas (T-cell) from B-cell Lymphomas and Pseudolymphomas. CD1a is also expressed by some malignancies of T-cell lineage and in Histiocytosis X. CD1a is a … WebCD1a ist im Zuge der adaptiven Immunantwort beteiligt an der Antigenpräsentation von Lipid -, Lipopeptid - und Glykolipid - Antigenen gegenüber den T-Zell-Rezeptoren von NKT … WebCD1a is a 49 kD member of the immunoglobulin superfamily also known as T6 and R4. It is a type I membrane glycoprotein with structural similarities to MHC class I and is non-covalently associated with β 2 -microglobulin. CD1a plays a role in non-peptide glycolipid antigen presentation to CD1-restricted T cells. brazilian pedro