WebMay 6, 2024 · DOI: 10.3389/fimmu.2024.00740 Abstract Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly triggered by IgG-subclasses IgG1 and IgG3 through the IgG-Fc-receptor (FcγR) IIIa. WebThe lab has defined and is characterizing a family of Fc receptors, Type II FcRs, involved in immune suppression. These inhibitory and activating mechanisms alone do not fully explain how antibodies mediate the full range of effector responses.
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FcγR Binding and ADCC Activity of Human IgG Allotypes
WebProvides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug … WebThis is a Proprietary Laboratory Analyses (PLA) code, meaning that the code describes only one unique lab test made by a specific manufacturer or performed by a specific lab. Code … WebContact Us. Immunogenetics and Cellular Immunology Laboratory. Columbia University Medical Center/NewYork-Presbyterian Hospital. 630 W. 168th Street. VC Building, Room 15-204. New York, NY 10032. Phone Number: (212) 305-6941. Fax Number: (212) 305-3429. broken snake