Web011038 B6.FVB-Tg(Myh6-cre)2182Mds/J The cardiac-specific alpha myosin-heavy chain ( Myh6 ) promoter drives expression of cre in this transgenic strain. The promoter induces … WebAtoh1-Cre activities were detected in the developing inner ear, the hindbrain, the spinal cord, and the intestine. In the inner ear, Atoh1-Cre activities were confined to the sensory organs in which lacZ expression is detected in nearly all of …
curation results for Gene-Disease Validity - Clinical Genome
WebMYH6 14q11.2 ?: zeldzaam Cardiaal troponine C TNNC1 3p21.1 0%: zeldzaam Myosine essentieel lichte keten MYL3 3p21.3 0%: 0.1% Myopathie Myosine regulatoir lichte keten MYL2 12q24.1 2%: 1.6% Myopathie Actine ACTC 15q11.1 0%: zeldzaam Titine TTN 2q31.2 ?: zeldzaam Muscle Lim CSRP3 11p15.1 2%: zeldzaam Web11 jan. 2011 · The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. impawards wallpaper
A comprehensive analysis of gene expression changes in a high ... - Nature
Web23 jul. 2010 · Four mutations were found within the segment of the MYH6 gene encoding the motor domain. A 755G>C transversion (A230P, Fig. 1A) was detected in exon 8 in a 32-year-old female patient diagnosed in infancy with tricuspid atresia, hypoplastic right ventricle, large secundum ASD and valvular and supravalvular pulmonary stenosis. A Fontan … Web首先，建立特异性Cre小鼠，该小鼠中的Cre重组酶由特定启动子驱动，可在特定细胞或组织或全身表达Cre重组酶。 Cre重组的特异性由驱动Cre的启动子或增强子控制。 其次，需要建立Flox小鼠，即在该小鼠靶基因序列侧翼带有Lox位点。 将上述两种小鼠杂交繁育，子代中可以获得既带有Cre又带有Flox基因的小鼠，即条件性基因打靶（表达或敲除靶基因）小鼠 … Web21 okt. 2016 · Tat-interactive protein 60 (Tip60), encoded by the Kat5 gene, is a member of the MYST family of acetyltransferases. Cancer biology studies have shown that Tip60 induces the DNA damage response, apoptosis, and cell-cycle inhibition. Although Tip60 is expressed in the myocardium, its role in cardiomyocytes (CMs) is unclear. Earlier studies … impa workshops