Paclitaxel cancer research
WebOct 20, 2005 · Paclitaxel (Taxol) is currently used as the front-line chemotherapeutic agent in breast cancers ( 1 ); however, because the drug frequently induces drug resistance ( 2 – 4 ), probably through the activation of nuclear factor-κB (NF-κB; ref. 5 ), it is not useful in treating advanced breast cancer.
Paclitaxel cancer research
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WebThis is a publication by a member of the Early Detection Research Network. ... Superior therapeutic efficacy of nab-paclitaxel over cremophor-based paclitaxel in locally advanced and metastatic models of human pancreatic cancer. ... indicating that nab-PTX could potentially stop the progression of late-stage pancreatic cancer. WebApr 5, 2024 · The study is being conducted in patients who have advanced non-small cell lung cancer (NSCLC). The aim of the study is to see how effective the combination of fianlimab, cemiplimab, and chemotherapy is for treating advanced NSCLC, in comparison with cemiplimab and chemotherapy. The study is looking at several other research …
WebJul 18, 2024 · Background Although various clinical trials and real-life studies have tried to explore the value of nab-paclitaxel mono-chemotherapy for metastatic breast cancer (MBC), the safety and efficacy of nab-paclitaxel remain unclear which need to be systematically evaluated. Methods Electronic searches for prospective clinical trials … WebSep 9, 2014 · Paclitaxel has long been recognized to induce mitotic arrest, which leads to cell death in a subset of the arrested population. However, recent evidence …
WebApr 2, 2024 · The Six Transmembrane Epithelial Antigen of the Prostate 1 (STEAP1) protein has been indicated as an overexpressed oncoprotein in prostate cancer (PCa), associated with tumor progression and aggressiveness. Taxane-based antineoplastic drugs such as paclitaxel, docetaxel, or cabazitaxel, have been in … WebPaclitaxel is a type of chemotherapy. It is a treatment for a number of different cancer types. You pronounce paclitaxel as pac-lih-tax-ul. How does paclitaxel work? …
WebPaclitaxel is used as a first-line (adjuvant) treatment of node-positive breast cancer. Paclitaxel is used as a second line agent in breast cancer, as monotherapy for the …
WebAlthough the combination of AZD8186 and paclitaxel was well tolerated, limited clinical efficacy was observed in advanced gastric cancer with PTEN loss. Methods: In the phase Ib dose-escalation, subjects with advanced solid tumors received oral AZD8186 (60 mg or 120 mg; twice daily (BID); 5 days on/2 days off) plus intravenous paclitaxel (70 mg ... ias officers name wise listWebNab-paclitaxel (trade name Abraxane) is a nanoparticle albumin-bound formulation of paclitaxel that, in combination with gemcitabine, is currently the first-line treatment for pancreatic cancer. Here, we show that macrophages internalized nab-paclitaxel via macropinocytosis. The macropinocytic uptake of nab-paclitaxel induced macrophage ... ias officer training videoWebMar 29, 2024 · Paclitaxel (PTX) has been used for cancer treatment for decades and has become one of the most successful chemotherapeutics in the clinic and financially. However, serious problems with its use still exist, owing to its poor solubility and non-selective toxicity. With respect to these issues, recent advances have addressed the water solubility and … ias officers list in karnatakaWebApr 14, 2024 · Brief Summary: The aim of the study is to assess the efficacy of fenofibrate in either reversing and/or preventing the development of PIPN in breast cancer patients … ias officers detailsWebAll comparisons used a two-sided test at an alpha level of 20%. Survival analyses were adjusted for prior paclitaxel. Results: Final analysis was performed after a median follow-up of 29.5 months. Pelareorep was well tolerated. Patients in Arm A had more favourable baseline prognostic variables. ias officer upWebBackground We compared the efficacy of two different taxanes, docetaxel and paclitaxel, given either weekly or every 3 weeks, in the adjuvant treatment of breast cancer. … ias officer tushar sumeraWebOct 5, 2024 · Paclitaxel induced peripheral neuropathy (PIPN) is a major debilitating side effect of paclitaxel in patients with breast cancer with no fully known mechanisms. The aim of the study was to find out the possible risk factors for PIPN. Methods Eligible patients with node positive breast cancer undergoing chemotherapy with paclitaxel were assessed. monarch butterfly wreath