Phf23 17p
WebIn our body's cells, the PHF23 molecule, PHD finger protein 23, is one of our human genes. ... ⌊ Chromosome 17p genes
Phf23 17p
Did you know?
WebMechanistically, we demonstrate that PHF23, an H3K4me3 reader, directly binds the SIN3-HDAC complex through its N-terminus and represses its deacetylation activity on … Web7. feb 2024 · Besides this PHF23-regulated epigenetic mechanism, metabolic alterations have been observed in cancers with del(17p). ALOX15B deficiency leads to accumulation …
Web1. jan 2014 · The human PHF23 gene is located on chromosome 17p13.1 and contains 5 exons ( Fig. 1A ). The full-length cDNA and predicted amino acid sequences are shown in Fig. S1A. The PHF23 gene is highly evolutionarily conserved ( Fig. S1B ). The PHF23 protein consists of 403 amino acid residues and the relative molecular weight is 43.8 kDa. Web25. sep 2024 · Significance We identify PHF23, encoding an H3K4me3 reader, as a new TSG on chromosome 17p, which is frequently deleted in human cancers. Mechanistically, …
WebPHF23 has originally been identified as an autophagy-related gene using an approach of functional genomics.20 To follow up, we designed a series of experiments to further explore the poten-tial relationship between PHF23 and autophagy. It was noted that PHF23 overexpression failed to affect the occurrence of WebPHF23 is a 17p TSg In our unbiased in vivo tumorigenesis screening with an shRNA library targeting genes on mouse chromosome 11B3, syntenic to human chromosome 17p13, …
WebNational Center for Biotechnology Information
Web1. okt 2008 · NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function. 36: 17287853: 2007: A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia. 24: 29296821: infinity tv service indianapolisWebSIGNIFICANCE: We identify PHF23, encoding an H3K4me3 reader, as a new TSG on chromosome 17p, which is frequently deleted in human cancers. Mechanistically, PHF23 forms a previously unreported histone-modifying complex, the PSH complex, which regulates gene activation through a synergistic link between H3K4me3 and H3K27ac. infinity twist 4t10 36 mop refillWebA, NUP98 (top), PHF23 (middle), and the aberrant NP23 fusion protein (bottom). from publication: NUP98-PHF23 Is a Chromatin-Modifying Oncoprotein That Causes a Wide Array of Leukemias Sensitive to ... infinity twist dust mop headWeb3. júl 2024 · Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of acute myeloid leukemia (AML) and poor survival rate. Here, we report the molecular mechanisms by which NUP98-PHF23 ... infinity twist bridal setWeb4. mar 2024 · They first identified 121 newly diagnosed multiple myeloma patients (NDMM) with a del (17p) in >55% of plasma cells who were uniformly treated with intensive therapy, including an autologous stem cell transplantation (ASCT). One-third of these patients had an additional mutation in TP53. infinity two names necklace 10k white goldWebAmong them, the prevalent chromosome 17p deletions are associated with poor prognosis and can promote tumorigenesis more than TP53 loss. Here, we use multiple functional … infinity two pro驱动WebBioinformatic analysis and expression profile of human PHF23. The human PHF23 gene is located on chromosome 17p13.1 and contains 5 exons ().The full-length cDNA and predicted amino acid sequences are shown in Fig. S1A.The PHF23 gene is highly evolutionarily conserved (Fig. S1B).The PHF23 protein consists of 403 amino acid … infinity tyres vi