2024 Phf8 testis

Phf8 testis

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August undefined, 2024

WebMar 21, 2024 · PHF8 (PHD Finger Protein 8) is a Protein Coding gene. Diseases associated with PHF8 include Intellectual Developmental Disorder, X-Linked, Syndromic, Siderius … Webphf8. pathology cancer. breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma. melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer. antibodies and validation.

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PHF8 belongs to the family of ferrous iron and alpha-ketoglutarate-dependent hydroxylases superfamily., and is active as a histone lysine demethylase with selectivity for the di-and monomethyl states. PHF8 induces an EMT (epithelial to mesenchymal transition)-like process by upregulating key EMT transcription factors SNAI1 and ZEB1. WebTestis i On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). … offline search engine

Emerging Roles of JmjC Domain-Containing Proteins - ScienceDirect

WebJan 1, 2015 · PHF8/KDM7B: H3K9me2; H4K20me1: PHF2/KDM7C: H3K9me1: Yes and No b: JmjC only: JMJD6/PTDSR: H3R2me2, H4R3me2 a: ... (2010) have shown that KDM3C interacts with the histone methyltransferase WHISTLE in the mouse testis during steroidogenesis, the process whereby cholesterol is converted in the mitochondrial inner … WebPHF8 was immunoprecipitated from 0.35 mg HeLa (human cervix adenocarcinoma epithelial cell) treated with 10µM MG-132 for 6 hours, whole cell lysate 10 ug with ab280887 at 1/30 … WebThe PHF8 gene provides instructions for making a protein that is found in the cell nucleus, particularly in brain cells before and just after birth. The PHF8 protein is part of a group … offline search

Monitoring Mitochondrial Protein Import Using Mitochondrial …

Phf8 testis

WebThe depletion of PHF8 exhibited a significantly reduced proportion of embryos with migration behavior in MKN28 (G). ... We show that this pseudogene is mainly transcribed in testis and can produce ... WebJul 22, 2010 · Plant homeodomain finger protein 8 (PHF8) is an X-related histone demethylase that contains a plant homeodomain and a catalytic Jumonji C (JMJC) domain with specificity for repressive...

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WebFeb 5, 2024 · PHF8. PHD finger protein 8. Gene ID: 23133, updated on 4-Nov-2024. Gene type: protein coding. Also known as: KDM7B; JHDM1F; MRXSSD; ZNF422. See all … WebExpression of PHF8 (JHDM1F, KDM7B, KIAA1111, ZNF422) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.

WebMay 5, 2024 · The checkpoint kinase ATR [ATM (ataxia-telangiectasia mutated) and rad3-related] is a master regulator of DNA damage response. Yet, how ATR activity is regulated remains to be investigated. We report here that histone demethylase PHF8 (plant homeodomain finger protein 8) plays a key role in ATR acti … WebDec 1, 2024 · Horton et al. (2010) determined the cocrystal structures of PHF8 or KIAA1718 in complex with a dimethylated peptide containing H3K4me3 and H3K9me2 at 2.2- or 2.4-angstrom resolution, respectively. The structures revealed that the PHD and Jumonji domains of these proteins acted in concert in substrate recognition. Interactions of …

WebOct 16, 2024 · Here we report the presence of PHF8-ps, a PHF8 retrotransposed pseudogene in the mouse genome, which has no disruptions in its coding sequence. We showed that … WebPHD finger protein 8 is a jumonji domain containing protein. Like other members of the jumonji family, PHF8 may therefore play a role in histone demethylation. Mutations in …

WebTransmission is X-linked and the syndrome is caused by mutations in the PHF8 gene, localised to the p11.21 region of the X chromosome. ... Broad nasal tip Cleft upper lip Intellectual disability, mild Large hands Long face Oral cleft Cryptorchidism Decreased testicular size Low posterior hairline Preaxial hand polydactyly Scoliosis Synophrys .

WebJan 9, 2024 · Mutations in PHF8 gene are genetically associated with X-linked mental retardation. Here, Chen et al. show that Phf8 KO mouse have cognitive and synaptic plasticity impairment, and pharmacological ... offline search and helpWebMar 26, 2024 · גורם קרישה 8 מיוצר בכבד והוא חלק ממנגנון קרישת הדם. רמה גבוהה של גורם קרישה 8 מעוררת נטייה לקרישות יתר של הדם. רמה נמוכה ידועה בשם מחלת המופיליה מסוג A, המתבטאת בנטייה … offline security details reset formWebOct 16, 2024 · Here we report the presence of PHF8-ps, a PHF8 retrotransposed pseudogene in the mouse genome, which has no disruptions in its coding sequence. We showed that this pseudogene was specifically transcribed in testis and can produce a Phf8-ps protein in vivo. myers foodWebJun 15, 2010 · Recent studies have identified mutations in PHF8, an X-linked gene encoding a JmjC domain-containing protein, as a causal factor for X-linked mental retardation (XLMR) and cleft lip/cleft palate. offline securityWebPHF8 is a demethylase that acts on di- and monomethylated lysine 9 of histone H3 that binds near transcription start sites of active or poised genes (184). From: Emery and Rimoin's Principles and Practice of Medical Genetics (Sixth Edition), 2013 View all Topics Add to Mendeley About this page Epigenetics in Intellectual Disability offline security cameras amazonWebAug 15, 2014 · PHF8 promotes miR-21expression in human lung cancer cells, and in turn, miR-21 mediates the function of PHF8 in human lung cancer cells because miR-21 knockdown blocks PHF8 effects on lung cancer growth and apoptosis (Fig. 4). In conclusion, PHF8 is an oncogenic protein in human NSCLC and could serve as a prognostic factor. … offline seeding mars agentWebPHF8 (PHD finger protein 8) is a member of the jumonji family of proteins and contains a jumonji C (JmjC) domain. The JmjC proteins are predicted to be metalloenzymes that play a role a chromatin remodeling and histone demethylation. myers foodservice equipment